Bioinformatics and computational biology, C. elegans, Developmental biology, Epigenetics and epigenomics, Functional genomics and systems biology, Gene regulation and expression, Genome analysis and sequencing, Non-coding DNA and RNA, Imaging and microscopy, Protein-protein, DNA-protein, and RNA-protein interactions, translation, and post-transcriptional regulation
Our research is aimed at uncovering the molecular mechanisms by which small RNA pathways related to microRNAs and RNA interference regulate gene expression throughout animal development. We are currently interested in understanding the tissue-specific functions of small RNA pathways, learning how small RNA pathways in the germline contribute to fertility and transgenerational epigenetic inheritance, and uncovering how small RNAs can be used to communicate between tissues and organisms. Our studies exploit integrated experimental approaches including molecular genetics, genomics, and cell biology in the model nematode and champion of small RNA biology, C. elegans.